Bio-Electrics: Hacking and Controlling the Local Cellular Machine Building Intelligence Workflows

Michael Levin, "Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration"

Abstract

Pattern formation, as occurs during embryogenesis or regeneration, is the crucial link between genotype and the functions upon which selection operates. Even cancer and aging can be seen as challenges to the continuous physiological processes that orchestrate individual cell activities toward the anatomical needs of an organism. Thus, the origin and maintenance of complex biological shape is a fundamental question for cell, developmental, and evolutionary biology, as well as for biomedicine. It has long been recognized that slow bioelectrical gradients can control cell behaviors and morphogenesis. Here, I review recent molecular data that implicate endogenous spatio-temporal patterns of resting potentials among non-excitable cells as instructive cues in embryogenesis, regeneration, and cancer. Functional data have implicated gradients of resting potential in processes such as limb regeneration, eye induction, craniofacial patterning, and head-tail polarity, as well as in metastatic transformation and tumorigenesis. The genome is tightly linked to bioelectric signaling, via ion channel proteins that shape the gradients, downstream genes whose transcription is regulated by voltage, and transduction machinery that converts changes in bioelectric state to second-messenger cascades. However, the data clearly indicate that bioelectric signaling is an autonomous layer of control not reducible to a biochemical or genetic account of cell state. The real-time dynamics of bioelectric communication among cells are not fully captured by transcriptomic or proteomic analyses, and the necessary-and-sufficient triggers for specific changes in growth and form can be physiological states, while the underlying gene loci are free to diverge. The next steps in this exciting new field include the development of novel conceptual tools for understanding the anatomical semantics encoded in non-neural bioelectrical networks, and of improved biophysical tools for reading and writing electrical state information into somatic tissues. Cracking the bioelectric code will have transformative implications for developmental biology, regenerative medicine, and synthetic bioengineering.

Eric Voegelin

Ecumenical Angst

The Driving Force behind Global Capitalism?

Etymological Origin from Google AI:

Ecumenical: late 16th century (in the sense ‘belonging to the universal Church’): via late Latin from Greek oikoumenikos from oikoumenē ‘the (inhabited) earth’.

Excerpts from above video:

Gnosticism

"For the cosmological civilizations of Mesopotamia, Syria, and Egypt, as well as for the peoples of the Mediterranean, the seventh century before Christ inaugurates the age of ecumenical empires."

"...the interpenetration of cultures reduce men who exercise no control over the proceedings of history to an extreme state of forlorness in the turmoil of the world, of intellectual disorientation, of material and spiritual insecurity. The loss of meaning that results from the breakdown of institutions, civilizations, and ethnic cohesion evokes attempts to regain an understanding of the meaning of human existence in the given conditions of the world."

"Among these efforts, which vary widely in depth and insight and substantive truth, are to be found the Stoic reinterpretation of man (to whom the polis has become meaningless) as the polites (citizen) of the cosmos, the Polybian vision of a pragmatic ecumene destined to be created by Rome, the mystery religions, the Heliopolitan slave cults, Hebrew apocalyptic, Christianity, and Manichaeism. And in this sequence, as one of the most grandiose of the new formulations of the meaning of existence belongs Gnosticism."

"Gnosticism: 1st-2nd Century Judeo-Christian movement denounced by the early Church."

Common thread:

"The experience of the world as an alien place into which man has strayed and from which he must find his way back home to the other world of his origin."

"The world is no longer well ordered, the cosmos, in which the Hellenic man felt at home, nor is it the Judeo-Christian world that God created and found good. Gnostic man no longer wishes to perceive in admiration the intrinsic order of the cosmos. For him the world has become a prison from which he wants to escape."

"From this attitude springs the programmatic formula of Gnosticism... Gnosis is 'the knowledge of who we were and what we became, of where we were and where-into we have been flung, of where-to we are hastening and where-from we are redeemed, of what birth is and what rebirth'."

"... escape from the world, means of deliverance."

"... the aim always is destruction of the old world and passage to the new. The instrument of salvation is gnosis itself - knowledge."

Summarizing the Post-Modern Muddled Theories of Neoliberalism...

....with all its' DEI/ ESG WEF Inspired  Cultural-Capital Bells and Whistles yet glosses over Intangible/ Virtual forms of Capital like Intellectual Property and Patents, which represent the overwhelming VALUE basis for Most Modern Tech Internet and "Rentier" Companies Today.

from Google AI:

IAS 38, titled "Intangible Assets," is an International Accounting Standard that lays down the criteria for recognizing, measuring, and disclosing intangible assets in financial statements. 

Key aspects of IAS 38

• Definition: An intangible asset is an identifiable non-monetary asset without physical substance. Examples include software, licenses, trademarks, patents, films, copyrights, and import quotas.
• Identifiability: An asset is considered identifiable if it's separable (can be sold, transferred, licensed) or if it arises from contractual or other legal rights.
• Recognition criteria:
  • It is probable that future economic benefits attributable to the asset will flow to the entity.
  • The cost of the asset can be measured reliably.
• Initial measurement: Intangible assets are initially measured at cost.
• Subsequent measurement:
  • Cost model: Carrying the asset at its initial cost minus any accumulated amortization and impairment losses.
  • Revaluation model: Revaluing the asset to its fair value at the revaluation date, less subsequent amortization and impairment losses (rarely used, as an active market is typically needed).
• Amortization: Intangible assets with a finite useful life are amortized systematically over that life.
• Impairment: Intangible assets (both finite and indefinite useful lives) are subject to impairment testing. An impairment loss is recognized if the carrying amount exceeds the recoverable amount.
• Derecognition: An intangible asset is derecognized on disposal or when no future economic benefits are expected from its use or disposal. 

Exclusions

Certain assets fall outside the scope of IAS 38, including goodwill acquired in a business combination (accounted for under IFRS 3) and internally generated goodwill. 

In essence, IAS 38 helps ensure that the value of a company's intangible assets is reflected accurately in its financial statements, contributing to transparency and better decision-making for investors and other stakeholders.